Fact Sheet


Full Title
New Technologies and Production Tools for Complex Protein Biologics

SME-targeted research for developing tools and technologies for high-throughput Research

Contract Number

ComplexINC conceptualizes and systematically generates advanced tool-kits to enable high-throughput assembly of complex biologics and metabolic pathways in eukaryotic expression systems, for micro- to large scale production of high-quality protein specimens for drug discovery and as bio-therapeutics. Essential parts of these tool-kits will be innovative next-generation HT DNA assembly pipelines for automated multigene expression construct generation, a superior synthetic viral genome, genetically engineered animal and yeast celllines with unique capabilities with respect to protein maturation and modification, as well as advanced methods for bioprocessing and integrated quality control. Putting these tools and production technologies in place will have a dramatic impact on the availability of challenging proteins and protein complexes including such of human origin, with tailor-made properties specifically geared towards their application in drug discovery and in the treatment of human diseases. The superior next generation technology platforms created within ComplexINC, the generated IP, protein targets and therapeutics will be commercially exploited, and serve as a nucleus to initiate a new start-up enterprise to commercialize high-end biologics discovery and production.

48 months (01/11/2011 – 31/10/2015)

Project Funding

European Molecular Biology Laboratory Grenoble
Dr Imre Berger 
Phone: +33 476 20 70 61


  • European Molecular Biology Laboratory Grenoble, France (Dr. Imre Berger)
  • CRELUX GmbH, Germany (Dr. Ismail Moarefi)
  • Helmholtz Centre for Infection Research, Germany (Dr. Joop van den Heuvel)
  • Instituto de Biologia Experimental e Tecnológica, Portugal (Prof. Dr. Manuel J. T. Carrondo)
  • Agencia Estatal Consejo Superior de Investigaciones Científicas, Spain (Dr. M. Cristina Vega)
  • Bioingenium, Spain (Dr. Ramon Ramon)
  • European Research and Project Office GmbH, Germany (Dr. Vera Schneider)